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Risk of acquisition of the change of a fabric taken from the same individual stvolovoj cages |
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| Risk of acquisition of the change of a fabric taken from the same individual stvolovoj cages |
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| According to recent research, the risk of acquisition of the change of a fabric taken from the same individual stvolovoj cages is “Fewer than 1 in 2500”. |
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According to recent research, this risk - “Fewer than 1 in 2500”. For the child in whom there is a direct family case record of a cell of the Sickle, Fanconi or Алмазная-Blackfan an anaemia and a little the inherited Leukaemia, the risk of the native brother or the child demanding change stvolovoj of a cage, can be much more above depending on many factors.
For a healthy family without dominating the inherited malignancy or a condition of this type the specified risk can be actually far less than 1 in 20 000 as only there were 4 or 5 registered cases of the changes taken from the same individual stvolovoj cord blood cells all over the world till now.
Problem of use taken from the same individual - one of intensive debate. The transplantation taken from the same individual stvolovoj cages is well established and used for set haematological and firm tumours. I would pull the reference on Gratwohl, etc. (2001) who has summed up transplantation activity stvolovoj cage Haematopoietic in Europe in 1999. From 18 720 first changes of 69 % (12 841) were taken from the same individual (this number includes 6 289 changes for a leukaemia, 30 % taken from the same individual; 8 219 changes for limfom, 92 % taken from the same individual; 3 302 changes for the firm tumours taken from the same individual of 99 %). This activity has increased essentially for last some years.
Debate does not consist in, whether there is a role for the transplantation of a cell of a primogenitor taken from the same individual, but will connect stvolovye blood cells, give to a source of these cells for use taken from the same individual in the future. In Cells of 4 Lives we believe, that as the cohort of patients which have kept cord blood all over the world, is accompanied, use of this resource taken from the same individual will replace usual procedures of mobilisation of a cell of a primogenitor of peripheral blood and now accessible methods of treatment. Unfortunately programs of storage of blood of a cord are yet enough old to let out samples for this use.
There is other debate concerning use taken from the same individual which is, that for the selected malignancy of blood genetic defect is predetermined also which would forbid use taken from the same individual as a therapy choice. Review Greaves (2002) has mentioned research where 1 % from 600 samples of blood was positive for PHONE AML1 of a gene of an alloy (the general leukaemogenic the marker).
This level, approximately 100 turn off cumulative norm of risk of ALL (with gene PHONE AML1), and clearly specifies, that clone transformation pre-leukaemic to frank illness is low, hits offering many are required for illness development. The concept of a multihit, changeable process can mean, that actually there is a role for stvolovyh the blood cells of a cord collected at a birth as the subsequent changes leukaemic, would not occur till some time after a birth
Use of the blood of a cord taken from the same individual - only partially a problem so many families wish to store confidentially them child’s blood of a cord for potential therapeutic statements for native brothers. Examples of it include patients in the one whom the native brother waits for warm transplantation where there can be possible use of the sample as cellular cardiomyoplasty during some moment for the following of 5 years.
Other examples include diabetic families, which make the informed choice to keep them child’s the blood of a cord based on now accessible certificate of research for based methods of treatment stvolovoj of a cage genoterapii for a diabetes which have shown the promise of results. |
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| About the Author |
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Wayne Channon, Director of Cells4Life Ltd, Stvolovaja a cage and the expert on storage of blood of a cord. http://www.cells4life.co.uk
Article source: http://www. ArticlesTake.com/author-wayne-channon-2540.html |
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